TNF receptor-associated factor 1; epstein-Barr virus-induced protein 6 (TRAF1, EBI6)

Function

• adapter protein & signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain & kinases
• thought to transmit signal of TNF-receptor 2
• mediates activation of NF-kappa-B & JNK & is involved in apoptosis
• the TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 & BIRC3 to TNFRSF1B/TNFR2 homotrimer (probable)
• heteromer with TRAF2 & associates with TNFRSF1B/TNFR2 through TRAF2
• associates with TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP & RIPK2
• interacts with BIRC2 & BIRC3 N-terminus
• interacts with NFATC2IP & with HIVEP3 (putative)

Structure

• the coiled coil domain mediates homo- & hetero- oligomerization
• the MATH/TRAF domain binds to receptor cytoplasmic domains
• contains 1 MATH domain

More general terms

• TRAF

Additional terms

• CD120b; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor 2; TNF-R2; tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; p75TNF receptor; TBPII; TBP-2 (TNFRSF1B, TNFBR, TNFR2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7185
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7185
• OMIM: https://mirror.omim.org/entry/601711
• UniProt: http://www.uniprot.org/uniprot/Q13077.html