tumor necrosis factor receptor superfamily member 27; X-linked ectodysplasin-A2 receptor; EDA-A2 receptor (EDA2R, TNFRSF27, XEDAR, UNQ2448/PRO5727/PRO34080)

Function

• receptor for EDA isoform A2, but not for EDA isoform A1
• mediates the activation of the NF-kappa-B & JNK pathways
• activation seems to be mediated by binding to TRAF3 & TRAF6
• associates with TRAF1, TRAF3 & TRAF6

Structure

contains 3 TNFR-Cys repeats

Compartment

membrane

Alternative splicing

named isoforms=3

More general terms

• tumor necrosis factor [TNF] receptor family
• glycoprotein

Additional terms

• tumor necrosis factor receptor superfamily member EDAR; Anhidrotic ectodysplasin receptor 1; ectodysplasin-A receptor; EDA-A1 receptor; ectodermal dysplasia receptor; downless homolog (EDAR, DL)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6040
• OMIM: https://mirror.omim.org/entry/300276
• UniProt: http://www.uniprot.org/uniprot/Q9HAV5.html