baculoviral IAP repeat-containing protein 3; inhibitor of apoptosis protein 1; HIAP-1; HIAP1; C-IAP2; TNFR2-TRAF-signaling complex protein 1; IAP homolog C; apoptosis inhibitor 2; API2; RING finger protein 49 (BIRC3, API2, IAP1, MIHC, RNF49)

Function

• apoptotic suppressor
• the N-terminal BIR domain interacts with TNF receptor associated factors 1 & 2 (TRAF1 & TRAF2) to form a heteromeric complex, which is then recruited to TNF receptor 2 (TNFR2)
• interacts with SMAC & with PRSS25; these interactions inhibit apoptotic suppressor activity

Structure

• belongs to the IAP family
• contains 3 BIR repeats
• contains 1 CARD domain
• contains 1 RING-type Zn+2 finger

Compartment

cytoplasm (putative)

Expression

• highly expressed in fetal lung, & kidney
• in adult, expression is mainly seen in lymphoid tissues, including spleen, thymus & peripheral blood lymphocytes

Pathology

• chromosomal translocation t(11;18)(q21;q21) involving BIRC3 with MALT1 is recurrent in low-grade MALT lymphoma

More general terms

• inhibitor of apoptosis protein
• ring finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=330
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:330
• OMIM: https://mirror.omim.org/entry/601721
• UniProt: http://www.uniprot.org/uniprot/Q13489.html