mucosa-associated lymphoid tissue lymphoma translocation protein 1; MALT lymphoma-associated translocation; paracaspase (MALT1, MLT)

Function

• enhances BCL10-induced activation of NF-kappa-B
• role in nuclear export of BCL10
• binds to TRAF6, inducing TRAF6 oligomerization & activation of its ligase activity
• has ubiquitin ligase activity
• MALT1-dependent BCL10 cleavage plays a role in T-cell antigen receptor-induced integrin adhesion
• binds through its Ig-like domains to BCL10
• forms oligomers which bind to TRAF6

Structure

• belongs to the peptidase C14B family
• contains 1 death domain
• contains 2 Ig-like C2-type domains

Compartment

• cytoplasm, perinuclear region, nucleus
• shuttles between the nucleus & cytoplasm
• found in perinuclear structures together with BCL10

Alternative splicing

named isoforms=2

Expression

• highly expressed in peripheral blood mononuclear cells
• expressed at lower levels in bone marrow, thymus & lymph node
• expressed at very low levels in colon & lung

Pathology

• chromosomal translocation t(11;18)(q21;q21) involving MALT1 with BIRC3 is found in ~50% of cytogenetically abnormal low-grade MALT lymphomas

More general terms

• cysteine proteinase; thiol proteinase
• phosphoprotein

Additional terms

• extranodal marginal zone B-cell lymphoma; low grade B-cell lymphoma of MALT [mucosa associated lymphoid tissue] type, MALToma

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10892
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10892
• OMIM: https://mirror.omim.org/entry/604860
• UniProt: http://www.uniprot.org/uniprot/Q9UDY8.html