B-cell lymphoma/leukemia 10; B-cell CLL/lymphoma 10; Bcl-10; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; CARD-containing molecule enhancing NF-kappa-B; cellular homolog of vCARMEN; cCARMEN; mammalian CARD-containing adapter molecule E10; mE10; cellular-E10; c-E10; CARD-like apoptotic protein; hCLAP (BCL10 CIPER CLAP)

Function

• promotes apoptosis, pro-caspase-9 maturation & activation of NF-kappa-B via NIK & IKK
• may be an adapter protein between upstream TNFR1-TRADD-RIP complex & the downstream NIK-IKK-IKAP complex
• substrate for MALT1
• phosphorylation results in dissociation from TRAF2 & binding to BIRC2/c-IAP2
• self-associates by CARD-CARD interaction & forms a tight complex with MALT1
• interacts with other CARD-proteins such as CARD9, CARD10, CARD11 & CARD14
• binds caspase-9 with its C-terminal domain
• interacts with TRAF2 & BIRC2/c-IAP2

Structure

contains 1 CARD domain

Compartment

• cytoplasm, perinuclear region
• appears to have a perinuclear, compact & filamentous pattern of expression
• also found in the nucleus of several types of tumor cells

Expression

ubiquitous

Pathology

• chromosomal translocation t(1;14)(p22;q32) involving BCL10 with IgH is recurrent in low-grade MALT lymphoma; although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations may occur via the Ig somatic hypermutation mechanism resulting in nucleotide transitions
• mutations seen in some MALT lymphoma, follicular lymphoma, germ cell tumors & mesothelioma

Laboratory

• BCL10 Ag in tissue

More general terms

• bcl protein (B-cell leukemia/lymphoma protein)
• caspase recruitment domain protein (CARD protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8915
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8915
• OMIM: https://mirror.omim.org/entry/603517
• UniProt: http://www.uniprot.org/uniprot/O95999.html