caspase recruitment domain-containing protein 10; CARD-containing MAGUK protein 3; carma 3 (CARD10, CARMA3)

Function

• activates NF-kappa-B via BCL10 & IKK
• CARD10 & BCL10 bind to each other by CARD-CARD interaction
  • they both participate in a complex with MALT1, where MALT1 binds to BCL10 (putative)

Structure

contains 1 CARD domain

Compartment

cytoplasm (putative)

Expression

• expressed in adult heart, kidney & liver
• lower expression in intestine, placenta, muscle & lung
• also found in fetal lung, liver & kidney

More general terms

• caspase recruitment domain protein (CARD protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29775
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29775
• OMIM: https://mirror.omim.org/entry/607209
• UniProt: http://www.uniprot.org/uniprot/Q9BWT7.html