caspase activation & recruitment (CARD) domain

Introduction

Consists of six alpha helices, some similarity to death domain & death effector domains.

Mediates interaction between large prodomain caspases & their corresponding upstream activator adaptors.

Proteins containing card domains include RAIDD, caspase-1, caspase-2, caspase-4, caspase-9, c-IAP1, c-IAP2, ICEBERG & C. elegans ced-3 & ced-4.

More general terms

• domain

Additional terms

• caspase recruitment domain protein (CARD protein)