Death domain-containing protein CRADD; Caspase & RIP adapter with death domain; RIP-associated protein with a death domain (CRADD, RAIDD)

Function

• apoptotic adaptor molecule specific for caspase-2 & FASL/TNF receptor-interacting protein RIP
• in the presence of RIP & TRADD, CRADD recruites caspase-2 to the TNFR-1 signalling complex
• interacts with LRDD

Structure

• contains 1 death domain involved in binding of RIP
• the CARD domain mediates the interaction with caspase-2
• contains 1 CARD domain

Expression

• constitutively expressed in most tissues
• high expression in adult heart, testis, liver, skeletal muscle, fetal liver & kidney

More general terms

• pro apoptotic protein

Database

• UniProt: http://www.uniprot.org/uniprot/P78560.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8738
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8738
• OMIM: https://mirror.omim.org/entry/603454