leucine-rich repeat & death domain-containing protein (p53-induced protein with a death domain, LRDD, PIDD)

Function

• promotes apoptosis downstream of p53
• component of the DNA damage/stress response pathway
• associates with NEMO/IKBKG & RIP1
• enhances sumoylation & ubiquitination of NEMO/IKBKG,
• associates with CASP2/caspase-2 & CRADD/RAIDD
  • induces activation of CASP2
• interacts with FADD & MAP-kinase activating death domain/MADD
• forms a complex with IKBKG & with RIP1
• forms a complex named PIDDosome with CASP2 & CRADD
• induced by gamma-irradiation

Expression

ubiquitous

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/605247
• UniProt: http://www.uniprot.org/uniprot/Q9HB75.html