Fas ligand; tumor necrosis factor ligand superfamily member 6; Fas antigen ligand; CD95L protein; apoptosis antigen ligand; APTL; CD178 (FASLG, APT1LG1, FASL, TNFSF6)
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Function
- cytokine that binds to FAS (CD95, TNFRSF6), a receptor that transduces the apoptotic signal into cells
- may be involved in cytotoxic T-cell mediated apoptosis & in T-cell development
- FasL-mediated cytotoxicity & perforin-mediated target cell lysis appear to be the 2 major effector pathways in T-cell cytotoxicity[3]
- FasL-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both
- binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects
- the soluble form derives from the membrane form by proteolytic processing
Structure
- homotrimer (probable)
- N-glycosylated
- belongs to the tumor necrosis factor family
Compartment
- cell membrane, secreted
- may be released into the extracellular fluid, probably by cleavage from the cell surface
Alternative splicing
named isoforms=2
Expression
Pathology
- defects in FASL are the cause of autoimmune lymphoproliferative syndrome type 1B
More general terms
- CD antigen
- plasma membrane protein
- glycoprotein
- oligomerizing protein
- tumor necrosis factor (TNF) family protein
References
- ↑ Cory S. Apoptosis. Fascinating death factor. Nature. 1994 Jan 27;367(6461):317-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7509455
- ↑ Nagata S, Golstein P. The Fas death factor. Science. 1995 Mar 10;267(5203):1449-56. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7533326
- ↑ 3.0 3.1 Lacronique V, Mignon A, Fabre M, Viollet B, Rouquet N, Molina T, Porteu A, Henrion A, Bouscary D, Varlet P, Joulin V, Kahn A. Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat Med. 1996 Jan;2(1):80-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8564847
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=356
- ↑ UniProt http://www.uniprot.org/uniprot/P48023.html
- ↑ FASLGbase; Note: FASLG mutation db http://bioinf.uta.fi/FASLGbase/
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=FASLG
- ↑ Wikipedia; Note: FAS-ligand entry http://en.wikipedia.org/wiki/FAS_ligand
Database
- OMIM: https://mirror.omim.org/entry/134638
- OMIM: https://mirror.omim.org/entry/601859
- UniProt: http://www.uniprot.org/uniprot/P48023.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=356
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:356
- Kegg: http://www.genome.jp/dbget-bin/www_bget?