Fas ligand; tumor necrosis factor ligand superfamily member 6; Fas antigen ligand; CD95L protein; apoptosis antigen ligand; APTL; CD178 (FASLG, APT1LG1, FASL, TNFSF6)

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Function

Structure

Compartment

  • cell membrane, secreted
  • may be released into the extracellular fluid, probably by cleavage from the cell surface

Alternative splicing

named isoforms=2

Expression

Pathology

More general terms

References

  1. Cory S. Apoptosis. Fascinating death factor. Nature. 1994 Jan 27;367(6461):317-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7509455
  2. Nagata S, Golstein P. The Fas death factor. Science. 1995 Mar 10;267(5203):1449-56. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7533326
  3. 3.0 3.1 Lacronique V, Mignon A, Fabre M, Viollet B, Rouquet N, Molina T, Porteu A, Henrion A, Bouscary D, Varlet P, Joulin V, Kahn A. Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat Med. 1996 Jan;2(1):80-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8564847
  4. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=356
  5. UniProt http://www.uniprot.org/uniprot/P48023.html
  6. FASLGbase; Note: FASLG mutation db http://bioinf.uta.fi/FASLGbase/
  7. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=FASLG
  8. Wikipedia; Note: FAS-ligand entry http://en.wikipedia.org/wiki/FAS_ligand

Database