tumor necrosis factor receptor superfamily member 6B; decoy receptor for Fas ligand; decoy receptor 3; DcR3; M68 (TNFRSF6B, DCR3, TR6, UNQ186/PRO212)

Function

• decoy receptor for the cytotoxic ligands TNFS14/LIGHT & TNFSF6/FASL
• protects against apoptosis

Structure

contains 4 TNFR-cys repeats

Compartment

secreted

Expression

• expressed in fetal lung, brain & liver
• expressed in adult stomach, spinal cord, lymph node, trachea, spleen, colon & lung

Pathology

• highly expressed in several primary tumors from colon, stomach, rectum, esophagus & in SW480 colon carcinoma cells

More general terms

• tumor necrosis factor [TNF] receptor family
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8771
• OMIM: https://mirror.omim.org/entry/603361
• UniProt: http://www.uniprot.org/uniprot/O95407.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8771