perforin-1; P1; lymphocyte pore-forming protein; PFP; cytolysin (PRF1 PFP)

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Function

Structure

Compartment

Expression

repressed by contact with target cells

Pathology

Laboratory

Comparative biology

More general terms

References

  1. Persechini PM et al Channel-forming activity of the perforin N-terminus and a putative alpha-helical region homologous with complement C9. Biochemistry. 1992 Jun 2;31(21):5017-21. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1599928
  2. 2.0 2.1 Ojcius DM et al Cytolytic and ion channel-forming properties of the N terminus of lymphocyte perforin. Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4621-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1711204
  3. 3.0 3.1 Kagi D, Vignaux F, Ledermann B et al Fas and perforin pathways as major mechanisms of T cell- mediated cytotoxicity. Science. 1994 Jul 22;265(5171):528-30. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7518614
  4. 4.0 4.1 Kagi D, Ledermann B et al Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature. 1994 May 5;369(6475):31-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8164737
  5. UniProt http://www.uniprot.org/uniprot/P14222.html
  6. PRF1base; Note: PRF1 mutation db http://bioinf.uta.fi/PRF1base/
  7. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=PRF1
  8. Wikipedia; Note: perforin entry http://en.wikipedia.org/wiki/perforin

Database