cytotoxic (suppressor) T cell (CD8+, CTL)
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Characteristics
- CD3, CD8+ cells.
- development of immature T-cell precursors (thymocytes) to CD8 T-cells correlates with their T-cell receptor specificity for major histocompatibility complex class 1 molecules.
- absence of ZNF67 expression results in CD8+ cell commitment.
CD8+ T-cells are involved in immune response to intracellular antigens & in cutaneous cytotoxic disorders.
Normally 30% of circulating T-cells.
Pool size: 1 x 10E11, 1/2 life = 167 days
Pathology
- viral antigens can lead to misguided activation of CD8+ T-cells & development of lymphoproliferative disorders[2]
More general terms
Additional terms
References
- ↑ Murasko DM & Berstein ED, Immunology of Aging, In: Principles of Geriatric Medicine, 4th ed,, Hazzard et al (eds), McGraw-Hill, NY, 1999, pg 99
- ↑ 2.0 2.1 Wenzel J et al, The role of cytotoxic skin-homing CD8+ lymphocytes in cutaneous T-cell lymphoma and pityriasis lichenoides J Am Acad Dermatol 2005; 53:422 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16112347