CD3
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Function
- associates with the T-cell receptor as the TcR/CD3 complex
- mediates signal transduction
Structure
- 90% of CD3 proteins contain gamma or delta & epsilon & zeta homodimers
- single cells contain both gamma-epsilon(2) -zeta(2) & delta-epsilon(2)-zeta(2) CD3/TCR complexes
- in 10% of CD3, zeta homodimers are replaced by zeta-eta heterodimer
Expression
- thymocytes
- peripheral T cells
- NK cells
- Purkinje cells of cerebellum
Pathology
- expressed in T cell lymphomas ~80%
Laboratory
- most specific T cell marker
- CD3 cells in specimen
More general terms
Additional terms
- CD3 omega subunit
- T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain; CD3d (CD3D, T3D)
References
- ↑ Springer TA. Adhesion receptors of the immune system. Nature. 1990 Aug 2;346(6283):425-34. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1974032
- ↑ Altman A, Coggeshall KM, Mustelin T. Molecular events mediating T cell activation. Adv Immunol. 1990;48:227-360. Review. No abstract available. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/1693465
- ↑ <Internet> http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ UniProt http://www.uniprot.org/uniprot/P09693.html