endothelin-1 receptor; endothelin A receptor; hET-AR; ETA-R; ET-A (EDNRA, ETA, ETRA)

Function

• receptor for endothelin-1
• mediates its action by association with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
• The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3
• interacts with HDAC7 & HTATIP

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Alternative splicing

named isoforms=4

Expression

• isoforms 1, 3 4 are expressed in a variety of tissues: aorta, cerebellum > lung, atrium, cerebral cortex > placenta, kidney, adrenal gland, duodenum, colon, ventricle & liver; no expression in umbilical vein endothelial cells
• within the placenta, isoforms 1,2,3 & 4 are expressed in the villi & stem villi vessels

More general terms

• endothelin receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1909
• OMIM: https://mirror.omim.org/entry/131243
• UniProt: http://www.uniprot.org/uniprot/P25101.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1909