histone acetyltransferase KAT5; 60 kD Tat-interactive protein; Tip60; histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; lysine acetyltransferase 5; cPLA(2)-interacting protein (KAT5, HTATIP, TIP60)

Function

• catalytic subunit of the NuA4 histone acetyltransferase complex
• directly acetylates & activates ATM
• in case of HIV1 infection, interaction with HIV1 Tat protein leads to KAT5 polyubiquitination & targets it to degradation
• sumoylated by UBE2I at Lys-430 & Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies
• phosphorylated on Ser-86 & Ser-90; enhanced during G2/Mphase
• phosphorylated form has a higher activity
• ubiquitinated by MDM2, leading to its proteasome-dependent degradation
• autoacetylation at Lys-327 is required for proper function
• interacts with the cytoplasmic tail of APP & APBB1/FE65 (putative)
• interacts with PLA2G4A/CPLA2, EDNRA & HDAC7
• interacts with TRIM24 & TRIM68
• forms a complex with SENP6 & UBE2I in response to UV irradiation

Structure

• belongs to the MYST (SAS/MOZ) family
• contains 1 C2HC-type Zn+2 finger

Compartment

• nucleus, nucleolus, cytoplasm, perinuclear region
• upon stimulation with EDN1, exported from the nucleus to the perinuclear region
• UV irradiation induces translocation into nuclear bodies

Alternative splicing

named isoforms=4

More general terms

• protein subunit
• acyltransferase
• phosphoprotein
• nuclear protein
• zinc finger protein

Component of

• NuA4 histone acetyltransferase (HAT) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10524
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10524
• OMIM: https://mirror.omim.org/entry/601409
• UniProt: http://www.uniprot.org/uniprot/Q92993.html