tripartite motif-containing protein 68 (Ring finger protein 137, SSA protein SS-56, SS-56, TRIM68, RNF137, SS56)

Structure

• belongs to the TRIM/RBCC family
• contains 1 B box-type zinc finger
• contains 1 B30.2/SPRY domain
• contains 1 RING-type zinc finger

Compartment

cytoplasm, perinuclear region

Expression

• expressed in all tissues
• high expression in spleen & in fetal liver

Pathology

• target of immune response in patients with:
  • systemic lupus erythematosus (SLE)
  • primary Sjoegren syndrome
  • HIV-1 infection

More general terms

• tripartite motif-containing protein (trim protein)

Database

• UniProt: http://www.uniprot.org/uniprot/Q6AZZ1.html