phospholipase-A2 [PLA2] type 4; cytoplasmic phospholipase A2 (cPLA2)
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Function
- marked preference for sn-2 arachidonate in phospholipid
- Ca+2-dependent phosphorylation & activation by MAP kinase (3)
Compartment
- cytoplasm
- Ca+2-binding translocates cytoplasmic PLA2 to membrane
More general terms
More specific terms
References
- ↑ Liscovitch M. Crosstalk among multiple signal-activated phospholipases. Trends Biochem Sci. 1992 Oct;17(10):393-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1455508
- ↑ Glaser KB, Mobilio D, Chang JY, Senko N. Phospholipase A2 enzymes: regulation and inhibition. Trends Pharmacol Sci. 1993 Mar;14(3):92-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8488570
- ↑ Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716514