sentrin-specific protease 6; SUMO-1-specific protease 1; sentrin/SUMO-specific protease SENP6 (SENP6, KIAA0797, SSP1, SUSP1, FKSG6)

Function

• protease that deconjugates SUMO1, SUMO2 & SUMO3 from targeted proteins
• processes preferentially poly-SUMO2 & poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 & SUMO3 precursors
• deconjugates SUMO1 from RXRA, leading to transcriptional activation
• role in chromosome alignment & spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex
• desumoylates PML & CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation
• also desumoylates RPA1, thus preventing recruitment of RAD51 to the foci of DNA damage
• protein modification; protein sumoylation
• interacts with RXRA
• forms a complex with KAT5-TIP60 & UBE2I in response to UV irradiation
• interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation

Structure

• belongs to the peptidase C48 family

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• highly expressed in reproductive organs, such as testis, ovary & prostate

More general terms

• sentrin-specific protease (SUMO-specific protease)
• nuclear protein
• phosphoprotein

Additional terms

• small ubiquitin-related modifier 1; SUMO-1; sentrin; ubiquitin-like protein SMT3C; SMT3 homolog 3; ubiquitin-homology domain protein PIC1; ubiquitin-like protein UBL1; GAP-modifying protein 1; GMP1 (SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl43)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26054
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26054
• OMIM: https://mirror.omim.org/entry/605003
• UniProt: http://www.uniprot.org/uniprot/Q9GZR1.html