centromere protein H; CENP-H; interphase centromere complex protein 35; centromere autoantigen H (CENPH, ICEN35)

Function

• component of the CENPA-NAC complex
• kinetochore function
• chromosome segregation during mitosis
• required for efficient alignment of the chromosomes on a metaphase plate
• self-associates
• interacts directly with CENPK
• interacts with KIF2C & NDC80
• interacts with TRIM36 (putative)

Structure

belongs to the centromere protein H family

Compartment

• nucleus
• chromosome, centromere, kinetochore
• associates with active centromere-kinetochore complexes throughout the cell cycle
• colocalizes with inner kinetochore plate proteins CENPA & CENPC1 during interphase & metaphase

More general terms

• centromere protein

Component of

• CENPA-NAC (nucleosome-associated) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64946
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64946
• OMIM: https://mirror.omim.org/entry/605607
• UniProt: http://www.uniprot.org/uniprot/Q9H3R5.html