CENPA-NAC (nucleosome-associated) complex

Function

• nucleosome-associated complex
• assembly of kinetochore proteins
• mitotic progression
• chromosome segregation
• recruits CENPA-CAD complex (nucleosome distal)
• incorporation of newly synthesized CENPA into centromeres

Structure

• consists of:
  • CENPA, CENPC, CENPH, CENPM, CENPN, CENPT, MLF1IP/CENPU

More general terms

• molecular complex