proliferation-associated nuclear element protein 1: centromere protein M; CENP-M; interphase centromere complex protein 39 (CENPM, C22orf18, ICEN39, PANE1)

Function

• component of the CENPA-NAC complex

Compartment

• nucleus, cytoplasm, chromosome, centromere, kinetochore
• nuclear in non-confluent cells
• cytoplasmic in confluent or dividing cells (putative)
• localizes in the kinetochore domain of centromeres

Alternative splicing

named isoforms=3

Expression

• isoform 3 is expressed in:
  • spleen > heart, prostate, ovary
  • resting CD19 B-cells
  • B-lineage chronic lymphocytic leukemia (B-CLL) cells
  • activated B-cells (weakly expressed)
• isoform 1 is expressed in:
  • activated CD19 cells
  • resting CD19 B-cells (weakly expressed)

More general terms

• nuclear protein

Component of

• CENPA-NAC (nucleosome-associated) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79019
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79019
• OMIM: https://mirror.omim.org/entry/610152
• UniProt: http://www.uniprot.org/uniprot/Q9NSP4.html