centromere protein C 1; CENP-C; centromere autoantigen C; interphase centromere complex protein 7 (CENPC1 CENPC ICEN7)

Function

• component of the CENPA-NAC (nucleosome-associated) complex
• binds to DAXX

Compartment

• nucleus, centromere, kinetochore
• localizes exclusively in the kinetochore domain of centromeres

Pathology

• antibodies against CENPC are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins

More general terms

• DNA-binding protein
• phosphoprotein

Component of

• CENPA-NAC (nucleosome-associated) complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q03188.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1060
• OMIM: https://mirror.omim.org/entry/117141