centromere protein U (CENP-U, CENP-U50, CENP-50, interphase centromere complex protein 24, MLF1-interacting protein, KSHV latent nuclear antigen-interacting protein 1, MLF1IP, CENPU, ICEN24, KLIP1)

Function

• component of the CENPA-NAC
• also involved in transcriptional repression
• interacts with MLF1

Compartment

• cytoplasm, nucleus, kinetochore
• localizes in the kinetochore domain of centromeres

Alternative splicing

named isoforms=2

Expression

• expressed in testis, fetal liver, thymus, bone marrow > lymph nodes, placenta, colon & spleen
• present in B-cells, T-cells, epithelial cells, fibroblasts

Pathology

• interacts with the N-terminal domain of Kaposi's sarcoma- associated herpesvirus latent nuclear antigen
• expressed at high levels in glioblastoma cell lines

More general terms

• nuclear protein
• phosphoprotein

Component of

• CENPA-NAC (nucleosome-associated) complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q71F23.html