E3 ubiquitin-protein ligase TRIM36; tripartite motif-containing protein 36; Zn+2-binding protein Rbcc728; RING finger protein 98 (TRIM36 RBCC728 RNF98)

Function

• E3 ubiquitin-protein ligase
• mediates ubiquitination & subsequent proteasomal degradation of target proteins
• involved in chromosome segregation & cell cycle regulation
• may play a role in the acrosome reaction & fertilization
• interacts with CENPH (putative)

Structure

• belongs to the TRIM/RBCC family
• contains 2 B box-type Zn+2 fingers
• contains 1 B30.2/SPRY domain
• contains 1 COS domain
• contains 1 fibronectin F3 module
• contains 1 RING-type Zn+2 finger

Compartment

• cytoplasm (putative)
• cytoplasmic vesicle, secretory vesicle, acrosome (putative)
• cytoskeleton (putative)
• found in the acrosomal region of elongated spermatids & mature sperm (putative)

Expression

• highly expressed in testis, prostate & brain
• weakly expressed in kidney, lung & heart

More general terms

• tripartite motif-containing protein (trim protein)
• E3 ubiquitin ligase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55521
• OMIM: https://mirror.omim.org/entry/609317
• UniProt: http://www.uniprot.org/uniprot/Q9NQ86.html