centromere protein K (CENP-K, interphase centromere complex protein 37, protein AF-5alpha, p33, CENPK, ICEN37, FKSG14)

Function

• component of the CENPA-CAD complex

Compartment

• nucleus, centromere
• localizes exclusively in the centromeres

Expression

• expressed in several fetal organs with highest levels in fetal liver
• in adults, it is weakly expressed in lung, placenta

Pathology

• chromosomal aberrations involving CENPK are a cause of acute leukemias
• chromosomal translocation t(5;11)(q12;q23) with MLL

More general terms

• nuclear protein
• phosphoprotein

Component of

• CENPA-CAD (nucleosome distal) complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BS16.html