acute leukemia
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Etiology
- acute lymphoblastic leukemia (ALL)
- acute mixed cell leukemia (AMML)
- acute myeloid leukemia (AML)
- acute null-cell leukemia
- mast cell leukemia
Genetics
- see specific form
- very high levels of TdT have been detected in some forms of acute leukemia
- overexpression of stathmin
- t(11;19)(q23;p13.3) involving MLLT1 with MLL
- t(11;19)(q23;p13.1) involving ELL with MLL
- t(9;11)(p22;q23) involving MLLT3 with MLL
- translocation resulting in MLL-EEN fusion gene
Laboratory
- complete blood count (CBC)
- peripheral blood smear
- flow cytometry
- bone marrow aspirate[2]
- bone marrow biopsy
- acute & chronic leukemia fusion transcript panel
- acute leukemia markers
Differential diagnosis
Management
- treat specific etiology
More general terms
More specific terms
- acute lymphoblastic leukemia (ALL)
- acute mixed cell (lineage) leukemia (AMML)
- acute myeloid leukemia (AML)
- acute null-cell leukemia (acute undifferentiated leukemia)
- mast cell leukemia
Additional terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
- ↑ 2.0 2.1 Vardiman JW, Rumble RB, Smith AT, Thomas NE Initial Diagnostic Workup of Acute Leukemia Guideline from the College of American Pathologists and the American Society of Hematology. http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/acute-leukemia-methodology.pdf