ENL (eleven-nineteen leukemia) proto oncogene protein; protein ENL; YEATS domain-containing protein 1 (MLLT1 ENL LTG19 YEATS1)

Function

• capable of activating transcription from synthetic reporter genes in both lymphoid & myeloid cells

Structure

contains 1 YEATS domain

Compartment

nucleus

Pathology

• chromosomal translocation t(11;19)(q23;p13.3) involving MLLT1 with MLL/HRX is associated with acute leukemias; the result is a rogue activator protein

More general terms

• proto oncogene protein
• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q03111.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4298
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4298
• OMIM: https://mirror.omim.org/entry/159556