endophilin-A2; EEN fusion partner of MLL; endophilin-2; extra eleven-nineteen leukemia fusion gene protein; EEN; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1 (SH3GL1, CNSA1 SH3D2B)

Function

• implicated in endocytosis
• may recruit other proteins to membranes with high curvature (putative)
• interacts with ARC (putative)
• interacts with SYNJ1 & DNM1
• interacts with PDCD6IP

Structure

• an N-terminal amphipathic helix, the BAR domain & a 2nd amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature & bind curved membranes
• belongs to the endophilin family
• contains 1 BAR domain
• contains 1 SH3 domain

Compartment

• cytoplasm (putative)
• early endosome membrane
• peripheral membrane
• associated with postsynaptic endosomes in hippocampal neurons

Expression

• ubiquitous
• high expression in pancreas, placenta, prostate, testis & uterus

Pathology

• in some cases of acute leukemia, a translocation results in formation of a MLL-EEN fusion gene

More general terms

• SH3-containing GRB2-like protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6455
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6455
• OMIM: https://mirror.omim.org/entry/601768
• UniProt: http://www.uniprot.org/uniprot/Q99961.html