activity-regulated cytoskeleton-associated protein (activity-regulated gene 3.1 protein homolog, Arg3.1, ARC/ARG3.1, ARC KIAA0278)
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Function
- required for consolidation of synaptic plasticity as well as formation of long-term memory (memory consolidation)
- regulates endocytosis of AMPA receptors in response to synaptic activity
- required for homeostatic synaptic scaling of AMPA receptors (putative)
- interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 & DNM2/DYN2 (putative)
Structure
belongs to the ARC/ARG3.1 family
Compartment
- cytoplasm, cytoskeleton (putative), endosome (putative) acrosome
- cell junction, synapse, postsynaptic cell membrane, postsynaptic density, cell projection, dendrite (putative), dendritic spine (putative)
- associated with the cell cortex of neuronal soma & dendrites
- enriched in postsynaptic density of dendritic spines
- associated with the sperm tail (putative)