dynamin 2 (DNM2, DYN2)

Function

• microtubule-associated GTPase involved in producing microtubule bundles
• involved in vesicular trafficking processes, including endocytosis
• interacts with SHANK1, SHANK2, SH3BP4 & NOSTRIN

GTP + H2O <--> GDP + phosphate

Structure

• belongs to the dynamin family
• contains 1 GED domain
• contains 1 PH domain

Compartment

• cytoplasm, cytoskeleton
• cell junction
• synapse, postsynaptic cell membrane, postsynaptic density

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

Pathology

• defects in DNM2 are a cause of
  • centronuclear myopathy autosomal dominant
  • dominant intermediate Charcot-Marie-Tooth disease B

More general terms

• dynamin
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P50570.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1785
• OMIM: https://mirror.omim.org/entry/160150
• OMIM: https://mirror.omim.org/entry/602378
• OMIM: https://mirror.omim.org/entry/606482
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1785