nostrin; eNOS trafficking inducer; nitric oxide synthase trafficker; nitric oxide synthase traffic inducer (BM247 homolog)
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Function
- multivalent adapter protein
- may decrease NOS3 activity by inducing its translocation away from the plasma membrane
- interacts with DAB2
- interacts with NOS3, DNM2, WASL & CAV1
Structure
- homotrimer
- contains 1 FCH domain necessary for membrane targeting
- contains 1 SH3 domain, mediates interaction with NOS3, DNM2 & WASL
Compartment
- cell membrane, cytoplasmic side
- cytoplasmic vesicle
- cytoplasm, cytoskeleton
- enriched in selected actin structures
Alternative splicing
named isoforms=3
Expression
- expressed at highest levels in heart, kidney, placenta & lung
- lowest levels in brain, thymus & spleen
- present in vascular endothelial cells & placenta
Pathology
- over-expressed in placenta from women with pre-eclampsia