disabled homolog 2; differentially-expressed protein 2; DOC-2 (DAB2, DOC2)

Function

• component of the CSF-1 signal transduction pathway
• interacts with the globular tail of MYO6
• interacts with DAB2IP
• interacts with NOSTRIN (putative)
• binds to NPXY motif of the amyloid precursor protein (APP)

Structure

contains 1 PID domain

Compartment

• cytoplasmic vesicle,
• clathrin-coated vesicle membrane
• membrane, clathrin-coated pit
• colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles

Alternative splicing

named isoforms=3

Expression

• expressed in deep invaginations, inclusion cysts & the surface epithelial cells of the ovary
• also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart & small intestine

More general terms

• disabled homolog
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1601
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1601
• OMIM: https://mirror.omim.org/entry/601236
• UniProt: http://www.uniprot.org/uniprot/P98082.html