FCH domain

Introduction

A short N-terminal conserved region of about 60 amino acids found in protein involved in the regulation of cytoskeletal rearrangements, vesicular transport & endocytosis. It is followed by a coiled-coil region.

Proteins containing an FCH domain include:

• protein kinases with an SH2 domain:
  • Fps/fes proto-oncogene proteins
  • Fes related protein (fer)
• adaptor proteins with a C-terminal SH3 domain:
  • Schizosaccharomyces pombe CDC15 protein
  • CD2 cytoplasmic domain binding protein
  • mammalian Cdc42-interacting protein 4 (CIP4)
  • ammalian PACSIN proteins
• RhoGAP proteins

More general terms

• domain