Cdc42-interacting protein 4; protein Felic; salt tolerant protein; hSTP; thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10 (TRIP10, CIP4, STOT, STP)
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Function
- required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (putative)
- required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis
- binds to lipids such as phosphatidylinositol 4,5-bisphosphate & phosphatidylserine & promotes membrane invagination & the formation of tubules
- also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex
- actin polymerization may promote fission of membrane tubules to form endocytic vesicles
- required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells
- may be required for the lysosomal retention of FASLG/FASL
- Tyr phosphorylated
- also phosphorylated by protein kinase A
- interacts specifically with GTP-bound RHOQ
- interacts with DNM2 & PDE6G (putative)
- interacts specifically with GTP-bound CDC42
- interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, SRC, WAS/WASP & WASL/N-WASP
- interacts with ligand binding domain of the thyroid receptor in the presence of thyroid hormone
- may interact with CTNNB1 & HD/HTT
Structure
- belongs to the FNBP1 family
- contains 1 FCH domain
- contains 1 REM (Hr1) repeat
- contains 1 SH3 domain
Compartment
- cytoplasm, cytoskeleton. cytoplasm, cell cortex
- lysosome
- Golgi
- cell membrane
- translocates to the plasma membrane in response to insulin stimulation; this may require active RHOQ (putative)
- localizes to cortical regions coincident with F-actin, to lysosomes & to sites of phagocytosis in macrophages
- also localizes to the Golgi; this requires AKAP9
- isoform 5: cytoplasm, perinuclear region
Alternative splicing
named isoforms=5
Expression
- expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus & trachea
- induced by adriamycin treatment; this effect is counteracted by HGF/SF
- expression is diminished during differentiation