solute carrier family 2 member 4; glucose transporter type 4, insulin-responsive; GLUT-4 (SLC2A4, GLUT4)

Function

• insulin-regulated facilitative glucose transporter
• insulin recruits GLUT4 to the plasma membrane
• binds to DAXX
• interacts via its N-terminus with SRFBP1
• sumoylated

Structure

• belongs to the major facilitator superfamily, sugar transporter (TC 2.A.1.1) family, glucose transporter subfamily

Compartment

• intracytoplasmic membrane, perinuclear region
• localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized
• the dileucine internalization motif is critical for intracellular sequestration
• insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation (putative)

Expression

• expressed in skeletal & cardiac muscles; brown & white fat

Pathology

• defects in SLC2A4 may be a cause of diabetes mellitus type 2 non-insulin dependent (NIDDM)
• defects in SLC2A4 may be a cause of certain post-receptor defects in NIDDM
• the variant in position Ile-383 is found in a small number of NIDDM patients, but seems not to be found in nondiabetic subjects

More general terms

• glucose transporter
• solute carrier family 2 (SLC2, SLC2A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6517
• OMIM: https://mirror.omim.org/entry/125853
• OMIM: https://mirror.omim.org/entry/138190
• UniProt: http://www.uniprot.org/uniprot/P14672.html