serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein, p49/STRAP) (SRFBP1)

Function

• may be involved in regulating transcriptional activation of cardiac genes during the aging process
• may play a role in biosynthesis &/or processing of SLC2A4 in adipose cells
• interacts with SRF
• forms complexes with SRF & SRF cofactors ARID2, MYOCD & NKX2-5
• interacts with the N-terminus of SLC2A4 (putative)

Compartment

cytoplasm, perinuclear region

Expression

• abundantly expressed in heart & skeletal muscle, & at much lower levels in brain & lung
• up-regulated in adult heart (at protein level)

More general terms

• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1534
• UniProt: http://www.uniprot.org/uniprot/Q8NEF9.html