serum response factor; SRF (SRF)
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Function
- transcription factor & DNA-binding protein
- binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS)
- required for cardiac differentation & maturation
- binds DNA as a multimer, probably a dimer
- interacts with MLLT7/FOXO4, NKX3A & SSRP1
- interacts with ARID2 & SRFBP1
- forms complexes with ARID2, MYOCD, NKX2-5 & SRFBP1
- SRF binding to RAP74 may be important for SRF-activated transcription[4]
- phosphorylated by PRKDC
Structure
contains 1 MADS-box domain
Compartment
More general terms
References
- ↑ Alberts et al Molecular Biology of the Cell, 2nd ed. 1989, pg 566
- ↑ UniProt http://www.uniprot.org/uniprot/P11831.html
- ↑ Berk AJ. Regulation of eukaryotic transcription factors by post- translational modification. Biochim Biophys Acta. 1989 Nov 2;1009(2):103-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2529903
- ↑ 4.0 4.1 Joliot V, Demma M, Prywes R. Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor. Nature. 1995 Feb 16;373(6515):632-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7854423