general transcription factor IIF subunit 1; general transcription factor IIF 74 kD subunit; transcription initiation factor IIF subunit alpha; TFIIF-alpha; transcription initiation factor RAP74 (GTF2F1, RAP74)
Jump to navigation
Jump to search
Function
- large subunit of TFIIF
- serum response factor (SRF) binding to RAP74 may be important for SRF-activated transcription
- interacts with RAP30 & CTDP1
- interacts with TAF6/TAFII80
- phosphorylated on Ser & other residues by TAF1 & casein kinase 2-like kinases
- may have serine/threonine kinase activity & autophosphorylate on Ser-385 & Thr-389[2]
Structure
belongs to the TFIIF alpha subunit family
Compartment
More general terms
References
- ↑ Joliot V, Demma M, Prywes R. Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor. Nature. 1995 Feb 16;373(6515):632-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7854423
- ↑ 2.0 2.1 Rossignol M, Keriel A, Staub A, Egly JM. Kinase activity and phosphorylation of the largest subunit of TFIIF transcription factor. J Biol Chem. 1999 Aug 6;274(32):22387-92. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10428810
- ↑ UniProt http://www.uniprot.org/uniprot/P35269.html