RNA polymerase II subunit A C-terminal domain phosphatase; TFIIF-associating CTD phosphatase (CTDP1, FCP1)

Function

• processively dephosphorylates Ser-2 & Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase 2 subunit
• phosphorylated
• in the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity
• phosphorylation is required for the physical interaction with GTF2F1
• homodimer
• interacts with GTF2F1
• interacts with WDR77, SNRPB & SNRNP70

Structure

• contains 1 BRCT domain
• contains 1 FCP1 homology domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• ubiquitously expressed
• isoform 3 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney & placenta

Pathology

• defects in CTDP1 are a cause of congenital cataracts facial dysmorphism & neuropathy syndrome

More general terms

• nuclear protein
• protein subunit
• phosphoprotein
• phosphoprotein phosphatase

Component of

• RNA polymerase-2

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9150
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9150
• OMIM: https://mirror.omim.org/entry/604168
• OMIM: https://mirror.omim.org/entry/604927
• UniProt: http://www.uniprot.org/uniprot/Q9Y5B0.html