RNA polymerase-2 CTD consensus repeat
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Function
- the largest subunit of eukaryotic RNA polymerase 2 contains an unsusual C-terminal domain comprising multiple repeats of the consensus sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser
- 52 in mice[2] or mammals[3]
- 42 in Drosophila
- 26 in yeast
- unphosphorylated CTD consensus repeat serves as binding site for TFIID anchoring RNA polymerase 2 complex at start site
- phosphorylation by TFIIH K subunit releases attachment to TFIID
- c-abl phosphorylates CTD on Tyr
More general terms
Additional terms
- RNA polymerase 2 largest subunit; RPB1; RNA polymerase 2 subunit A; RNA polymerase 2 subunit B1 (POLR2A)
- RNA polymerase-2
References
- ↑ UI89295557
- ↑ 2.0 2.1 Drapkin R, Reinberg D. Transcription. The essential twist. Nature. 1994 Jun 16;369(6481):523-4. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8202151
- ↑ 3.0 3.1 Drapkin R, Reinberg D. The multifunctional TFIIH complex and transcriptional control. Trends Biochem Sci. 1994 Nov;19(11):504-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7855896