casein kinase 2
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Function
- CK2 is not responsive to known 2nd messengers
- phosphorylation of many substrates by CK2 is stimulated 2-3 fold by polyamines
- CK2 can use either ATP or GTP
- CK2 recognizes the sequence [ST]XX[EDS*T*], where the [ST] represents the Ser/Thr phosphorylation site, X is any non basic residue & [EDS*T*] is a negatively charged site representing an acidic residue or phosphorylated Ser/Thr
- this specificity lends CK2 to participate in hierarchal phosphorylation of proteins with the motif [ST]XX[ST]
- it may be of significance that several nuclear proteins (including SV40 large T antigen) contain nuclear localization signals proximal to CK2 consensus phosphorylation sites[4].
- participates in Wnt signaling
- phosphorylates Ser-392 of p53/TP53 following UV irradiation
Structure
More general terms
Component of
References
- ↑ Luscher B, Christenson E, Litchfield DW, Krebs EG, Eisenman RN. Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation. Nature. 1990 Apr 5;344(6266):517-22. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2157164
- ↑ Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2238044 (recognition sequence)
- ↑ Davletov B, Sontag JM, Hata Y, Petrenko AG, Fykse EM, Jahn R, Sudhof TC. Phosphorylation of synaptotagmin I by casein kinase II. J Biol Chem. 1993 Mar 25;268(9):6816-22. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8454654
- ↑ 4.0 4.1 Allende JE, Allende CC. Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation. FASEB J. 1995 Mar;9(5):313-23. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7896000