casein kinase 2-beta chain (phosvitin, CSNK2B ,CK2N, G5A)

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Function

  • not catalytically active by itself
  • stimulates the activity of the alpha & alpha' subunits 5-10 fold[1]
  • stabilizes the alpha & alpha' subunits & alters their interactions with substrates & inhibitors
  • phosphorylated by alpha subunit

Structure

More general terms

Component of

References

  1. 1.0 1.1 Luscher B, Christenson E, Litchfield DW, Krebs EG, Eisenman RN. Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation. Nature. 1990 Apr 5;344(6266):517-22. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2157164
  2. Allende JE, Allende CC. Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation. FASEB J. 1995 Mar;9(5):313-23. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7896000

Database