cardiac-specific homeobox protein CSX; homeobox protein Nkx-2.5; homeobox protein NK-2 homolog E; NKX2-5 (CSX, NKX25, NKX2E)

Function

• implicated in commitment to &/or differentiation of the myocardial lineage
• acts as a transcriptional activator of ANF in cooperation with GATA4 (putative)
• interacts with HIPK1 & HIPK2, but not HIPK3
• interacts with the C-terminal Zn+2 finger of GATA4 through its homeobox domain
• interacts with JARID2 which represses its ability to activate transcription of ANF
• interacts with FBLIM1

Structure

• belongs to the NK-2 homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (probable)

Expression

expressed only in the heart

Pathology

• defects in NKX2-5 are the cause of
  • atrial septal defect
  • tetralogy of Fallot

More general terms

• homeobox protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1482
• OMIM: https://mirror.omim.org/entry/108900
• OMIM: https://mirror.omim.org/entry/187500
• OMIM: https://mirror.omim.org/entry/600584
• UniProt: http://www.uniprot.org/uniprot/P52952.html