homeodomain-interacting protein kinase 3; homolog of protein kinase YAK1; Fas-interacting serine/threonine protein kinase; FIST, androgen receptor-interacting nuclear protein kinase; ANPK (HIPK3, DYRK6, FIST3, PKY)

Function

• negatively regulates apoptosis via FADD phosphorylation
• interacts with & stabilizes ligand-bound androgen receptor
• enhances androgen receptor-mediated transcription
• may act as a transcriptional corepressor for NK homeodomain transcription factors
• interacts with Nkx1-2, FAS & DAXX
• probably part of a complex consisiting of HIPK3, FAS & FADD

Compartment

nuclear & cytoplasmic

Expression

• overexpressed in multidrug resistant cells
• highly expressed in heart & skeletal muscle

More general terms

• serine/threonine kinase

Database

• OMIM: https://mirror.omim.org/entry/604424
• UniProt: http://www.uniprot.org/uniprot/Q9H422.html