atrial natriuretic factor/peptide (ANF, ANP)

Function

• endogenous anti-hypertensive agent secreted from the cardiac atria
• derived from a larger precursor protein (NPPA)

Mechanism of action

• enhances salt & water excretion
• blocks aldosterone & renin secretion
• inhibits the action of angiotensin II & vasopressin
• inhibits smooth muscle contraction
• net effect is a decrease in blood pressure & blood volume

More general terms

• natriuretic peptides A
• natriuretic hormone

Additional terms

• ANP receptor-C; atrial natriuretic peptide clearance receptor; atrial natriuretic peptide C-type receptor; ANPRC; ANP-C; NPR-C (NPR3 ANPRC)
• atrial natriuretic factor/peptide/hormone (ANF/ANP/ANH) in plasma
• atrial natriuretic peptide receptor A; atrial natriuretic peptide A-type receptor; ANPRA; ANP-A; NPR-A; guanylate cyclase; GC-A (NPR1, ANPRA)

Database

• OMIM: https://mirror.omim.org/entry/108780