atrial natriuretic peptide receptor A; atrial natriuretic peptide A-type receptor; ANPRA; ANP-A; NPR-A; guanylate cyclase; GC-A (NPR1, ANPRA)
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Function
- receptor for atrial natriuretic peptide
- has guanylate cyclase activity on binding of ANF
- phosphorylation of the protein kinase-like domain is required for full activation by ANP (putative)
Structure
- belongs to the adenylyl cyclase class-4/guanylyl cyclase family
- contains 1 guanylate cyclase domain
- contains 1 protein kinase domain
Compartment
membrane
Pathology
- polymorphism in ANF receptor type A gene associated with left ventricular hypertrophy & decreased serum atrial natriuretic factor[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P16066.html
- ↑ 2.0 2.1 Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 716
- ↑ Rabattu S et al, Association of atrial natriuretic peptide and type A natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension. J Am Coll Cardiol 2006, 48:499 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16875975
London B, Natriuretic peptides and cardiac hypertrophy J Am Coll Cardiol 2006, 48:506 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16875976