natriuretic peptides A; CDD-ANF; prepronatriodilatin; contains: cardiodilatin-related peptide; CDP; contains: atrial natriuretic factor; ANF; atrial natriuretic peptide; ANP (NPPA, PND)

Function

• hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, & vasodilation
• also plays a role in female pregnancy by promoting trophoblast invasion & spiral artery remodeling in uterus
• specifically binds & stimulates the cGMP production of the NPR1 receptor
• binds the clearance receptor NPR3
• cleaved by CORIN upon secretion to produce the functional hormone

Structure

belongs to the natriuretic peptide family

Compartment

secreted

Pathology

• defects in NPPA are the cause of familial atrial fibrillation type 6

Polymorphism

• there are two different prepronatriodilatin alleles
• one codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide

More general terms

• secreted protein

More specific terms

• atrial natriuretic factor/peptide (ANF, ANP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4878
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4878
• OMIM: https://mirror.omim.org/entry/108780
• OMIM: https://mirror.omim.org/entry/612201
• UniProt: http://www.uniprot.org/uniprot/P01160.html