atrial natriuretic peptide-converting enzyme; corin; heart-specific serine proteinase ATC2; Pro-ANP-converting enzyme; transmembrane protease serine 10; contains: atrial natriuretic peptide-converting enzyme, N-terminal propeptide; atrial natriuretic peptide-converting enzyme, activated protease fragment (CORIN, CRN, TMPRSS10)

Function

• converts Pro-ANP to ANP
• cleaves Pro-ANP specifically between Arg-123 & Ser-124.

Structure

• type 2 membrane protein

Expression

highly expressed in heart

More general terms

• transmembrane serine protease
• glycoprotein

Additional terms

• atrial natriuretic factor/peptide (ANF, ANP)

Database

• OMIM: https://mirror.omim.org/entry/605236
• UniProt: http://www.uniprot.org/uniprot/Q9Y5Q5.html