protein Jumonji; Jumonji/ARID domain-containing protein 2 (JARID2, JMJ)

Function

• regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart & liver development, neural tube fusion process & hematopoiesis
• acts by modulating histone methyltransferase activity & promoting recruitment of histone methyltransferase complexes to their target genes
• binds DNA & mediates recruitment of the PRC2 complex to target genes in embryonic stem cells
• does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes
• in embryonic stem cells, associates with the PRC2 complex & inhibits trimethylation of Lys-27 of histone H3 (H3K27me3) by the PRC2 complex, thus playing a key role in differentiation of embryonic stem cells & normal development
• in cardiac cells, required to repress expression of cyclin-D1 CCND1) by activating methylation of Lys-9 of histone H3 (H3K9me) by the GLP1/EHMT1 & G9a/EHMT2 histone methyltransferases
• also acts as a transcriptional repressor of ANF via its interaction with GATA4 & NKX2-5
• participates in negative regulation of cell proliferation signaling
• associates with a histone methyltransferase complex containing GLP1/EHMT1 & G9a/EHMT2
• interacts with SUZ12; the interaction is direct
• interacts with GATA4 (via the N-terminal region)
• interacts with NKX2-5 (via the C-terminal region)
• interacts with RB1
• interacts with ZNF496 (putative)
• associates with the PRC2 complex, which includes EED, EZH1, EZH2, SUZ12, RBBP4 & AEBP2; JARID2 is probably not a core component of the PRC2 complex & associates to PRC2 via its interaction with SUZ12

Structure

• the ARID domain is required to target the PRC2 complex to its target genes (putative)
• the GSGFP motif is required for the interaction with SUZ12
• contains 1 ARID domain
• contains 1 JmjC domain
• contains 1 JmjN domain

Compartment

• nucleus
• colocalizes with the PRC2 complex on chromatin

Alternative splicing

named isoforms=2

Expression

• during embryogenesis, predominantly expressed in neurons & particularly in dorsal root ganglion cells

More general terms

• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3720
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3720
• OMIM: https://mirror.omim.org/entry/601594
• UniProt: http://www.uniprot.org/uniprot/Q92833.html